The Mellone Lab was featured in UConn Today – UConn cell biologist Barbara Mellone, her student Jason Palladino, and colleagues report in the cover article of the 10 February issue of Developmental Cell that they were able to make fake centromeres that fooled cells into rearranging their chromosomes.
Fluorescence images of mitotic cells with de novo centromeres from Drosophila melanogaster larval brains. The chromosomes are stained with DAPI (DNA, magenta) and CENP-C antibodies (kinetochore protein, green) and are shown within the outlines of fruit flies. (Courtesy of Barbara Mellone)
Read article in UConn Today
See cover story at Developmental Cell
MCB Associate Professor Barbara Mellone received a $2.6million R35-MIRA grant from the National Institute of Health to fund her research on an elusive yet vital chromosomal structure that all plant and animal share: the centromere. This five-year grant will support research efforts to determine the contribution of DNA repeats and centromere chromatin to the formation and proper function of these structures and to engineer centromeres using Drosophila as a model.